rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population
المؤلفون المشاركون
Liu, Huimin
Huang, Lina
Yuan, Kexin
Jia, Yunhe
Liu, Jingjing
Dong, Xiaoqun
Ren, Xiyun
Tian, Wenjing
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this study was to explore the association between polymorphisms in signal transducer and activator of transcription protein 3 (STAT3) and the risk of gastric cancer.
In the present study, a case-control study was conducted in which rs2293152 and rs744166 polymorphisms in STAT3 were analyzed in 209 Chinese patients with gastric cancer and 294 cancer-free controls.
The genotypes were determined by polymerase chain reaction restriction fragment length polymorphism method.
For the rs744166 polymorphism, the TC genotype (adjusted OR=0.60, 95% CI = 0.39–0.92, and P=0.020) and CC genotype (adjusted OR=0.41, 95% CI=0.21–0.80, and P=0.009) were associated with a decreased risk of gastric cancer compared to the TT genotype.
However, rs2293152 did not show any difference in gastric cancer risk between patients and controls in the CG/CC genotype compared to the GG genotype.
Besides, the SNP effects were additive to the effects of environmental factors without any interaction between them in the susceptibility to gastric cancer.
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
Additionally, polymorphisms in STAT3, along with environmental factors, might be associated with the development of gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Kexin& Liu, Huimin& Huang, Lina& Ren, Xiyun& Liu, Jingjing& Dong, Xiaoqun…[et al.]. 2014. rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-478838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Kexin…[et al.]. rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-478838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Kexin& Liu, Huimin& Huang, Lina& Ren, Xiyun& Liu, Jingjing& Dong, Xiaoqun…[et al.]. rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-478838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر