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rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population
Joint Authors
Liu, Huimin
Huang, Lina
Yuan, Kexin
Jia, Yunhe
Liu, Jingjing
Dong, Xiaoqun
Ren, Xiyun
Tian, Wenjing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to explore the association between polymorphisms in signal transducer and activator of transcription protein 3 (STAT3) and the risk of gastric cancer.
In the present study, a case-control study was conducted in which rs2293152 and rs744166 polymorphisms in STAT3 were analyzed in 209 Chinese patients with gastric cancer and 294 cancer-free controls.
The genotypes were determined by polymerase chain reaction restriction fragment length polymorphism method.
For the rs744166 polymorphism, the TC genotype (adjusted OR=0.60, 95% CI = 0.39–0.92, and P=0.020) and CC genotype (adjusted OR=0.41, 95% CI=0.21–0.80, and P=0.009) were associated with a decreased risk of gastric cancer compared to the TT genotype.
However, rs2293152 did not show any difference in gastric cancer risk between patients and controls in the CG/CC genotype compared to the GG genotype.
Besides, the SNP effects were additive to the effects of environmental factors without any interaction between them in the susceptibility to gastric cancer.
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
Additionally, polymorphisms in STAT3, along with environmental factors, might be associated with the development of gastric cancer.
American Psychological Association (APA)
Yuan, Kexin& Liu, Huimin& Huang, Lina& Ren, Xiyun& Liu, Jingjing& Dong, Xiaoqun…[et al.]. 2014. rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-478838
Modern Language Association (MLA)
Yuan, Kexin…[et al.]. rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-478838
American Medical Association (AMA)
Yuan, Kexin& Liu, Huimin& Huang, Lina& Ren, Xiyun& Liu, Jingjing& Dong, Xiaoqun…[et al.]. rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-478838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478838