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Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−
المؤلفون المشاركون
Yi, Fu
Wang, Yabin
Zhang, Xiaotian
Cao, Feng
Ma, Sai
Zhang, Zhengxun
Li, Xiujuan
Yuan, Yuan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Background.
Cardiac ischemia reperfusion (I/R) injury is associated with overproduction of reactive oxygen species (ROS).
Low frequency pulse magnetic fields (LFMFs) have been reported to decrease ROS generation in endothelial cells.
Whether LFMFs could assert protective effects on myocardial from I/R injury via ROS regulation remains unclear.
Methods.
To simulate in vivo cardiac I/R injury, neonatal rat cardiomyocytes were subjected to hypoxia reoxygenation (H/R) with or without exposure to LFMFs.
Cell viability, apoptosis index, ROS generation (including O2- and ONOO−), and NO production were measured in control, H/R, and H/R + LFMF groups, respectively.
Results.
H/R injury resulted in cardiomyocytes apoptosis and decreased cell viability, whereas exposure to LFMFs before or after H/R injury significantly inhibited apoptosis and improved cell viability (P<0.05).
LFMFs treatment could suppress ROS (including O2- and ONOO−) generation induced by H/R injury, combined with decreased NADPH oxidase activity.
In addition, LFMFs elevated NO production and enhanced NO/ONOO− balance in cardiomyocytes, and this protective effect was via the phosphorylation of endothelial nitric oxide synthase (eNOS).
Conclusion.
LFMFs could protect myocardium against I/R injury via regulating ROS generation and NO/ONOO− balance.
LFMFs treatment might serve as a promising strategy for cardiac I/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Sai& Zhang, Zhengxun& Yi, Fu& Wang, Yabin& Zhang, Xiaotian& Li, Xiujuan…[et al.]. 2013. Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Sai…[et al.]. Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-478974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Sai& Zhang, Zhengxun& Yi, Fu& Wang, Yabin& Zhang, Xiaotian& Li, Xiujuan…[et al.]. Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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