Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−
Joint Authors
Yi, Fu
Wang, Yabin
Zhang, Xiaotian
Cao, Feng
Ma, Sai
Zhang, Zhengxun
Li, Xiujuan
Yuan, Yuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
Cardiac ischemia reperfusion (I/R) injury is associated with overproduction of reactive oxygen species (ROS).
Low frequency pulse magnetic fields (LFMFs) have been reported to decrease ROS generation in endothelial cells.
Whether LFMFs could assert protective effects on myocardial from I/R injury via ROS regulation remains unclear.
Methods.
To simulate in vivo cardiac I/R injury, neonatal rat cardiomyocytes were subjected to hypoxia reoxygenation (H/R) with or without exposure to LFMFs.
Cell viability, apoptosis index, ROS generation (including O2- and ONOO−), and NO production were measured in control, H/R, and H/R + LFMF groups, respectively.
Results.
H/R injury resulted in cardiomyocytes apoptosis and decreased cell viability, whereas exposure to LFMFs before or after H/R injury significantly inhibited apoptosis and improved cell viability (P<0.05).
LFMFs treatment could suppress ROS (including O2- and ONOO−) generation induced by H/R injury, combined with decreased NADPH oxidase activity.
In addition, LFMFs elevated NO production and enhanced NO/ONOO− balance in cardiomyocytes, and this protective effect was via the phosphorylation of endothelial nitric oxide synthase (eNOS).
Conclusion.
LFMFs could protect myocardium against I/R injury via regulating ROS generation and NO/ONOO− balance.
LFMFs treatment might serve as a promising strategy for cardiac I/R injury.
American Psychological Association (APA)
Ma, Sai& Zhang, Zhengxun& Yi, Fu& Wang, Yabin& Zhang, Xiaotian& Li, Xiujuan…[et al.]. 2013. Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478974
Modern Language Association (MLA)
Ma, Sai…[et al.]. Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-478974
American Medical Association (AMA)
Ma, Sai& Zhang, Zhengxun& Yi, Fu& Wang, Yabin& Zhang, Xiaotian& Li, Xiujuan…[et al.]. Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NOONOO−. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478974