Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses
المؤلفون المشاركون
Lee, Jaehwi
Lee, Joo Young
Kim, Byung Hun
Lee, Yong Gyu
Cho, Jae Youl
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Cinnamaldehyde (CA) has been known to exhibit anti-inflammatory and anticancer effects.
Although numerous pharmacological effects have been demonstrated, regulatory effect of CA on the functional activation of monocytes and macrophages has not been fully elucidated yet.
To evaluate its monocyte/macrophage-mediated immune responses, macrophages activated by lipopolysaccharide (LPS), and monocytes treated with proaggregative antibodies, and extracellular matrix protein fibronectin were employed.
CA was able to suppress both the production of nitric oxide (NO) and upregulation of surface levels of costimulatory molecules (CD80 and CD69) and pattern recognition receptors (toll-like receptor 2 (TLR2) and complement receptor (CR3)).
In addition, CA also blocked cell-cell adhesion induced by the activation of CD29 and CD43 but not cell-fibronectin adhesion.
Immunoblotting analysis suggested that CA inhibition was due to the inhibition of phosphoinositide-3-kinase (PI3K) and phosphoinositide-dependent kinase (PDK)1 as well as nuclear factor-(NF-) κB activation.
In particular, thiol compounds with sulphydryl group, L-cysteine and dithiothreitol (DTT), strongly abrogated CA-mediated NO production and NF-κB activation.
Therefore, our results suggest that CA can act as a strong regulator of monocyte/macrophage-mediated immune responses by thiolation of target cysteine residues in PI3K or PDK1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Byung Hun& Lee, Yong Gyu& Lee, Jaehwi& Lee, Joo Young& Cho, Jae Youl. 2010. Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-478994
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Byung Hun…[et al.]. Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-478994
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Byung Hun& Lee, Yong Gyu& Lee, Jaehwi& Lee, Joo Young& Cho, Jae Youl. Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-478994
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478994
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر