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Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses
Joint Authors
Lee, Jaehwi
Lee, Joo Young
Kim, Byung Hun
Lee, Yong Gyu
Cho, Jae Youl
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cinnamaldehyde (CA) has been known to exhibit anti-inflammatory and anticancer effects.
Although numerous pharmacological effects have been demonstrated, regulatory effect of CA on the functional activation of monocytes and macrophages has not been fully elucidated yet.
To evaluate its monocyte/macrophage-mediated immune responses, macrophages activated by lipopolysaccharide (LPS), and monocytes treated with proaggregative antibodies, and extracellular matrix protein fibronectin were employed.
CA was able to suppress both the production of nitric oxide (NO) and upregulation of surface levels of costimulatory molecules (CD80 and CD69) and pattern recognition receptors (toll-like receptor 2 (TLR2) and complement receptor (CR3)).
In addition, CA also blocked cell-cell adhesion induced by the activation of CD29 and CD43 but not cell-fibronectin adhesion.
Immunoblotting analysis suggested that CA inhibition was due to the inhibition of phosphoinositide-3-kinase (PI3K) and phosphoinositide-dependent kinase (PDK)1 as well as nuclear factor-(NF-) κB activation.
In particular, thiol compounds with sulphydryl group, L-cysteine and dithiothreitol (DTT), strongly abrogated CA-mediated NO production and NF-κB activation.
Therefore, our results suggest that CA can act as a strong regulator of monocyte/macrophage-mediated immune responses by thiolation of target cysteine residues in PI3K or PDK1.
American Psychological Association (APA)
Kim, Byung Hun& Lee, Yong Gyu& Lee, Jaehwi& Lee, Joo Young& Cho, Jae Youl. 2010. Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-478994
Modern Language Association (MLA)
Kim, Byung Hun…[et al.]. Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-478994
American Medical Association (AMA)
Kim, Byung Hun& Lee, Yong Gyu& Lee, Jaehwi& Lee, Joo Young& Cho, Jae Youl. Regulatory Effect of Cinnamaldehyde on MonocyteMacrophage-Mediated Inflammatory Responses. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-478994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478994