The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases

المؤلفون المشاركون

Godoy, Alejandro
Li, Yun
Mohler, James L.
Azzouni, Faris

المصدر

Advances in Urology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-18، 18ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-12-25

دولة النشر

مصر

عدد الصفحات

18

التخصصات الرئيسية

الأمراض

الملخص EN

Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974.

Affected males are born with ambiguous external genitalia, despite normal internal genitalia.

The prostate is hypoplastic, nonpalpable on rectal examination and approximately 1/10th the size of age-matched normal glands.

Benign prostate hyperplasia or prostate cancer does not develop in these patients.

At puberty, the external genitalia virilize partially, however, secondary sexual hair remains sparse and male pattern baldness and acne develop rarely.

Several compounds have been developed to inhibit the 5 alpha-reductase isozymes and they play an important role in the prevention and treatment of many common diseases.

This review describes the basic biochemical properties, functions, tissue distribution, chromosomal location, and clinical significance of the 5 alpha-reductase isozyme family.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Azzouni, Faris& Godoy, Alejandro& Li, Yun& Mohler, James L.. 2011. The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-479043

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Azzouni, Faris…[et al.]. The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-479043

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Azzouni, Faris& Godoy, Alejandro& Li, Yun& Mohler, James L.. The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-479043

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-479043