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Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity
المؤلفون المشاركون
Delgado-Martos, María Jesús
Condezo-Hoyos, Luis
González, María Carmen
Rodríguez-Rodríguez, Pilar
Quintana-Villamandos, Begoña
Arnalich-Montiel, Ana
Martos-Rodríguez, Antonia
Delgado-Baeza, Emilio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study was to assess the effects of short-term esmolol therapy on coronary artery structure and function and plasma oxidative stress in spontaneously hypertensive rats (SHR).
For this purpose, 14-month-old male SHR were treated for 48 hours with esmolol (SHR-E, 300 μg/kg/min).
Age-matched untreated male SHR and Wistar Kyoto rats (WKY) were used as hypertensive and normotensive controls, respectively.
At the end of intervention we performed a histological study to analyze coronary artery wall width (WW), wall-to-lumen ratio (W/L), and media cross-sectional area (MCSA).
Dose-response curves for acetylcholine (ACh) and sodium nitroprusside were constructed.
We also assessed several plasma oxidative stress biomarkers, namely, superoxide scavenging activity (SOSA), nitrites, and total antioxidant capacity (TAC).
We observed a significant reduction in WW (P<0.001), W/L (P<0.05), and MCSA (P<0.01) and improved endothelium-dependent relaxation (AUCSHR-E = 201.2±33 versus AUCSHR = 97.5±21, P<0.05) in SHR-E compared with untreated SHR; no differences were observed for WW, MCSA, and endothelium-dependent relaxation by ACh at higher concentrations (10−6 to 10−4 mol/l) for SHR-E with respect to WKY.
SOSA (P<0.001) and nitrite (P<0.01) values were significantly higher in SHR-E than in untreated SHR; however, TAC did not increase after treatment with esmolol.
Esmolol improves early coronary artery remodeling in SHR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arnalich-Montiel, Ana& González, María Carmen& Delgado-Baeza, Emilio& Delgado-Martos, María Jesús& Condezo-Hoyos, Luis& Martos-Rodríguez, Antonia…[et al.]. 2014. Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479145
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arnalich-Montiel, Ana…[et al.]. Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-479145
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arnalich-Montiel, Ana& González, María Carmen& Delgado-Baeza, Emilio& Delgado-Martos, María Jesús& Condezo-Hoyos, Luis& Martos-Rodríguez, Antonia…[et al.]. Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479145
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479145
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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