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Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity
Joint Authors
Delgado-Martos, María Jesús
Condezo-Hoyos, Luis
González, María Carmen
Rodríguez-Rodríguez, Pilar
Quintana-Villamandos, Begoña
Arnalich-Montiel, Ana
Martos-Rodríguez, Antonia
Delgado-Baeza, Emilio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to assess the effects of short-term esmolol therapy on coronary artery structure and function and plasma oxidative stress in spontaneously hypertensive rats (SHR).
For this purpose, 14-month-old male SHR were treated for 48 hours with esmolol (SHR-E, 300 μg/kg/min).
Age-matched untreated male SHR and Wistar Kyoto rats (WKY) were used as hypertensive and normotensive controls, respectively.
At the end of intervention we performed a histological study to analyze coronary artery wall width (WW), wall-to-lumen ratio (W/L), and media cross-sectional area (MCSA).
Dose-response curves for acetylcholine (ACh) and sodium nitroprusside were constructed.
We also assessed several plasma oxidative stress biomarkers, namely, superoxide scavenging activity (SOSA), nitrites, and total antioxidant capacity (TAC).
We observed a significant reduction in WW (P<0.001), W/L (P<0.05), and MCSA (P<0.01) and improved endothelium-dependent relaxation (AUCSHR-E = 201.2±33 versus AUCSHR = 97.5±21, P<0.05) in SHR-E compared with untreated SHR; no differences were observed for WW, MCSA, and endothelium-dependent relaxation by ACh at higher concentrations (10−6 to 10−4 mol/l) for SHR-E with respect to WKY.
SOSA (P<0.001) and nitrite (P<0.01) values were significantly higher in SHR-E than in untreated SHR; however, TAC did not increase after treatment with esmolol.
Esmolol improves early coronary artery remodeling in SHR.
American Psychological Association (APA)
Arnalich-Montiel, Ana& González, María Carmen& Delgado-Baeza, Emilio& Delgado-Martos, María Jesús& Condezo-Hoyos, Luis& Martos-Rodríguez, Antonia…[et al.]. 2014. Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479145
Modern Language Association (MLA)
Arnalich-Montiel, Ana…[et al.]. Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-479145
American Medical Association (AMA)
Arnalich-Montiel, Ana& González, María Carmen& Delgado-Baeza, Emilio& Delgado-Martos, María Jesús& Condezo-Hoyos, Luis& Martos-Rodríguez, Antonia…[et al.]. Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479145