LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes

المؤلفون المشاركون

Oestvang, Janne
Johansen, Berit
Anthonsen, Marit W.

المصدر

Journal of Lipids

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-09-11

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري
علوم

الملخص EN

Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation.

A key component of LDL is lysophosphatidylcholine (lysoPC).

LysoPC is a strong proinflammatory mediator, and its mechanism is uncertain, but it has been suggested to be mediated via the platelet activating factor (PAF) receptor.

Here, we report that PAF triggers a pertussis toxin- (PTX-) sensitive intracellular signaling pathway leading to sequential activation of sPLA2, PLD, cPLA2, and AA release in human-derived monocytes.

In contrast, lysoPC initiates two signaling pathways, one sequentially activating PLD and cPLA2, and a second parallel PTX-sensitive pathway activating cPLA2 with concomitant activation of sPLA2, all leading to AA release.

In conclusion, lysoPC and PAF stimulate AA release by divergent pathways suggesting involvement of independent receptors.

Elucidation of monocyte lysoPC-specific signaling mechanisms will aid in the development of novel strategies for atherosclerosis prevention, diagnosis, and therapy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Oestvang, Janne& Anthonsen, Marit W.& Johansen, Berit. 2011. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479234

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Oestvang, Janne…[et al.]. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-479234

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Oestvang, Janne& Anthonsen, Marit W.& Johansen, Berit. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479234

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-479234