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LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes
Joint Authors
Oestvang, Janne
Johansen, Berit
Anthonsen, Marit W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation.
A key component of LDL is lysophosphatidylcholine (lysoPC).
LysoPC is a strong proinflammatory mediator, and its mechanism is uncertain, but it has been suggested to be mediated via the platelet activating factor (PAF) receptor.
Here, we report that PAF triggers a pertussis toxin- (PTX-) sensitive intracellular signaling pathway leading to sequential activation of sPLA2, PLD, cPLA2, and AA release in human-derived monocytes.
In contrast, lysoPC initiates two signaling pathways, one sequentially activating PLD and cPLA2, and a second parallel PTX-sensitive pathway activating cPLA2 with concomitant activation of sPLA2, all leading to AA release.
In conclusion, lysoPC and PAF stimulate AA release by divergent pathways suggesting involvement of independent receptors.
Elucidation of monocyte lysoPC-specific signaling mechanisms will aid in the development of novel strategies for atherosclerosis prevention, diagnosis, and therapy.
American Psychological Association (APA)
Oestvang, Janne& Anthonsen, Marit W.& Johansen, Berit. 2011. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479234
Modern Language Association (MLA)
Oestvang, Janne…[et al.]. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-479234
American Medical Association (AMA)
Oestvang, Janne& Anthonsen, Marit W.& Johansen, Berit. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479234