Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis
المؤلفون المشاركون
Gao, Huanqing
Yang, Yifan
Liu, Changjin
Li, Yuhao
Xu, Wenchun
Wang, Jianwei
Yamahara, Johji
Zuo, Guo-Wei
Li, Ying
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Oleanolic acid (OA), contained in more than 1620 plants and as an aglycone precursor for naturally occurred and synthesized triterpenoid saponins, is used in China for liver disorders in humans.
However, the underlying liver-protecting mechanisms remain largely unknown.
Here, we found that treatment of rats with OA (25 mg/kg/day, gavage, once daily) over 10 weeks diminished liquid fructose-induced excess hepatic triglyceride accumulation without effect on total energy intake.
Attenuation of the increased vacuolization and Oil Red O staining area was evident on histological examination of liver in OA-treated rats.
Hepatic gene expression profile demonstrated that OA suppressed fructose-stimulated overexpression of sterol regulatory element-binding protein-(SREBP-) 1/1c mRNA and nuclear protein.
In accord, overexpression of SREBP-1c-responsive genes responsible for fatty acid synthesis was also downregulated.
In contrast, overexpressed nuclear protein of carbohydrate response element-binding protein and its target genes liver pyruvate kinase and microsomal triglyceride transfer protein were not altered.
Additionally, OA did not affect expression of peroxisome proliferator-activated receptor-gamma- and -alpha and their target genes.
It is concluded that modulation of hepatic SREBP-1c-mediated expression of the genes responsible for de novo fatty acid synthesis plays a pivotal role in OA-elicited diminishment of fructose-induced fatty liver in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Changjin& Li, Ying& Zuo, Guo-Wei& Xu, Wenchun& Gao, Huanqing& Yang, Yifan…[et al.]. 2013. Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-479325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Changjin…[et al.]. Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-479325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Changjin& Li, Ying& Zuo, Guo-Wei& Xu, Wenchun& Gao, Huanqing& Yang, Yifan…[et al.]. Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-479325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر