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Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis
Joint Authors
Gao, Huanqing
Yang, Yifan
Liu, Changjin
Li, Yuhao
Xu, Wenchun
Wang, Jianwei
Yamahara, Johji
Zuo, Guo-Wei
Li, Ying
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oleanolic acid (OA), contained in more than 1620 plants and as an aglycone precursor for naturally occurred and synthesized triterpenoid saponins, is used in China for liver disorders in humans.
However, the underlying liver-protecting mechanisms remain largely unknown.
Here, we found that treatment of rats with OA (25 mg/kg/day, gavage, once daily) over 10 weeks diminished liquid fructose-induced excess hepatic triglyceride accumulation without effect on total energy intake.
Attenuation of the increased vacuolization and Oil Red O staining area was evident on histological examination of liver in OA-treated rats.
Hepatic gene expression profile demonstrated that OA suppressed fructose-stimulated overexpression of sterol regulatory element-binding protein-(SREBP-) 1/1c mRNA and nuclear protein.
In accord, overexpression of SREBP-1c-responsive genes responsible for fatty acid synthesis was also downregulated.
In contrast, overexpressed nuclear protein of carbohydrate response element-binding protein and its target genes liver pyruvate kinase and microsomal triglyceride transfer protein were not altered.
Additionally, OA did not affect expression of peroxisome proliferator-activated receptor-gamma- and -alpha and their target genes.
It is concluded that modulation of hepatic SREBP-1c-mediated expression of the genes responsible for de novo fatty acid synthesis plays a pivotal role in OA-elicited diminishment of fructose-induced fatty liver in rats.
American Psychological Association (APA)
Liu, Changjin& Li, Ying& Zuo, Guo-Wei& Xu, Wenchun& Gao, Huanqing& Yang, Yifan…[et al.]. 2013. Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-479325
Modern Language Association (MLA)
Liu, Changjin…[et al.]. Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-479325
American Medical Association (AMA)
Liu, Changjin& Li, Ying& Zuo, Guo-Wei& Xu, Wenchun& Gao, Huanqing& Yang, Yifan…[et al.]. Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats : Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-479325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479325