Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall
المؤلفون المشاركون
Rawish, Kojo R.
Fadare, Oluwole
المصدر
Case Reports in Obstetrics and Gynecology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-17
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Dedifferentiation is a phenomenon that is well characterized in a variety of tumors and is defined by the occurrence of a high-grade or undifferentiated tumor, typically unrecognizable regarding its line of differentiation, from a low-grade/borderline neoplasm.
This phenomenon has previously been described in 2 uterine leiomyosarcomas, but both were devoid of heterologous elements.
The authors describe herein a case of a dedifferentiated leiomyosarcoma of the uterus with osteoid heterologous elements, believed to be the first such reported case.
The original tumor was a high-grade leiomyosarcoma with large low-grade and leiomyoma-like areas and whose constituent cells displayed intense nuclear immunoreactivity for both estrogen receptor (ER) and progesterone receptor (PR) in approximately 30% of cells.
The tumor recurred six months after its resection as an undifferentiated sarcoma that was negative for smooth muscle markers, but which remained positive for ER and PR.
Osteoid production was only identified in the recurrent tumor and was significant in extent therein.
This case highlights the immunophenotypic changes that may occur in dedifferentiated leiomyosarcomas, and this possibility should be a consideration when an apparently undifferentiated sarcoma is identified in a patient with a history of uterine leiomyosarcoma.
In our case, the expression of ER and PR provided significant supportive evidence of the uterine origin of the recurrent tumor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rawish, Kojo R.& Fadare, Oluwole. 2012. Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall. Case Reports in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-479377
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rawish, Kojo R.& Fadare, Oluwole. Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall. Case Reports in Obstetrics and Gynecology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-479377
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rawish, Kojo R.& Fadare, Oluwole. Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall. Case Reports in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-479377
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479377
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر