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Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall
Joint Authors
Rawish, Kojo R.
Fadare, Oluwole
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Dedifferentiation is a phenomenon that is well characterized in a variety of tumors and is defined by the occurrence of a high-grade or undifferentiated tumor, typically unrecognizable regarding its line of differentiation, from a low-grade/borderline neoplasm.
This phenomenon has previously been described in 2 uterine leiomyosarcomas, but both were devoid of heterologous elements.
The authors describe herein a case of a dedifferentiated leiomyosarcoma of the uterus with osteoid heterologous elements, believed to be the first such reported case.
The original tumor was a high-grade leiomyosarcoma with large low-grade and leiomyoma-like areas and whose constituent cells displayed intense nuclear immunoreactivity for both estrogen receptor (ER) and progesterone receptor (PR) in approximately 30% of cells.
The tumor recurred six months after its resection as an undifferentiated sarcoma that was negative for smooth muscle markers, but which remained positive for ER and PR.
Osteoid production was only identified in the recurrent tumor and was significant in extent therein.
This case highlights the immunophenotypic changes that may occur in dedifferentiated leiomyosarcomas, and this possibility should be a consideration when an apparently undifferentiated sarcoma is identified in a patient with a history of uterine leiomyosarcoma.
In our case, the expression of ER and PR provided significant supportive evidence of the uterine origin of the recurrent tumor.
American Psychological Association (APA)
Rawish, Kojo R.& Fadare, Oluwole. 2012. Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall. Case Reports in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-479377
Modern Language Association (MLA)
Rawish, Kojo R.& Fadare, Oluwole. Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall. Case Reports in Obstetrics and Gynecology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-479377
American Medical Association (AMA)
Rawish, Kojo R.& Fadare, Oluwole. Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements : A Potential Diagnostic Pitfall. Case Reports in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-479377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479377