Network of microRNAs-mRNAs Interactions in Pancreatic Cancer
المؤلفون المشاركون
Naderi, Elnaz
Mostafaei, Mehdi
Mohamadkhani, Ashraf
Pourshams, Akram
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
MicroRNAs are small RNA molecules that regulate the expression of certain genes through interaction with mRNA targets and are mainly involved in human cancer.
This study was conducted to make the network of miRNAs-mRNAs interactions in pancreatic cancer as the fourth leading cause of cancer death.
Methods.
56 miRNAs that were exclusively expressed and 1176 genes that were downregulated or silenced in pancreas cancer were extracted from beforehand investigations.
MiRNA–mRNA interactions data analysis and related networks were explored using MAGIA tool and Cytoscape 3 software.
Functional annotations of candidate genes in pancreatic cancer were identified by DAVID annotation tool.
Results.
This network is made of 217 nodes for mRNA, 15 nodes for miRNA, and 241 edges that show 241 regulations between 15 miRNAs and 217 target genes.
The miR-24 was the most significantly powerful miRNA that regulated series of important genes.
ACVR2B, GFRA1, and MTHFR were significant target genes were that downregulated.
Conclusion.
Although the collected previous data seems to be a treasure trove, there was no study simultaneous to analysis of miRNAs and mRNAs interaction.
Network of miRNA-mRNA interactions will help to corroborate experimental remarks and could be used to refine miRNA target predictions for developing new therapeutic approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Naderi, Elnaz& Mostafaei, Mehdi& Pourshams, Akram& Mohamadkhani, Ashraf. 2014. Network of microRNAs-mRNAs Interactions in Pancreatic Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479395
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Naderi, Elnaz…[et al.]. Network of microRNAs-mRNAs Interactions in Pancreatic Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-479395
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Naderi, Elnaz& Mostafaei, Mehdi& Pourshams, Akram& Mohamadkhani, Ashraf. Network of microRNAs-mRNAs Interactions in Pancreatic Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479395
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479395
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر