Network of microRNAs-mRNAs Interactions in Pancreatic Cancer
Joint Authors
Naderi, Elnaz
Mostafaei, Mehdi
Mohamadkhani, Ashraf
Pourshams, Akram
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
MicroRNAs are small RNA molecules that regulate the expression of certain genes through interaction with mRNA targets and are mainly involved in human cancer.
This study was conducted to make the network of miRNAs-mRNAs interactions in pancreatic cancer as the fourth leading cause of cancer death.
Methods.
56 miRNAs that were exclusively expressed and 1176 genes that were downregulated or silenced in pancreas cancer were extracted from beforehand investigations.
MiRNA–mRNA interactions data analysis and related networks were explored using MAGIA tool and Cytoscape 3 software.
Functional annotations of candidate genes in pancreatic cancer were identified by DAVID annotation tool.
Results.
This network is made of 217 nodes for mRNA, 15 nodes for miRNA, and 241 edges that show 241 regulations between 15 miRNAs and 217 target genes.
The miR-24 was the most significantly powerful miRNA that regulated series of important genes.
ACVR2B, GFRA1, and MTHFR were significant target genes were that downregulated.
Conclusion.
Although the collected previous data seems to be a treasure trove, there was no study simultaneous to analysis of miRNAs and mRNAs interaction.
Network of miRNA-mRNA interactions will help to corroborate experimental remarks and could be used to refine miRNA target predictions for developing new therapeutic approaches.
American Psychological Association (APA)
Naderi, Elnaz& Mostafaei, Mehdi& Pourshams, Akram& Mohamadkhani, Ashraf. 2014. Network of microRNAs-mRNAs Interactions in Pancreatic Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479395
Modern Language Association (MLA)
Naderi, Elnaz…[et al.]. Network of microRNAs-mRNAs Interactions in Pancreatic Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-479395
American Medical Association (AMA)
Naderi, Elnaz& Mostafaei, Mehdi& Pourshams, Akram& Mohamadkhani, Ashraf. Network of microRNAs-mRNAs Interactions in Pancreatic Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479395