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A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate
المؤلفون المشاركون
Nieder, Carsten
Dalhaug, Astrid
Aandahl, Gro
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-16
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Patients with triple receptor-negative breast cancer often develop aggressive metastatic disease, which also might involve the brain.
In many cases, systemic and local treatment is needed.
It is important to consider the toxicity of chemo- and radiotherapy, especially when newly approved drugs become available.
Randomised studies leading to drug approval often exclude patients with newly diagnosed brain metastases.
Here we report our initial experience with eribulin mesylate and whole-brain radiotherapy (WBRT) in a heavily pretreated patient with multiple brain, lung, and bone metastases from triple receptor-negative breast cancer.
Eribulin mesylate was given after 4 previous lines for metastatic disease.
Two weeks after the initial dose, that is, during the first cycle, the patient was diagnosed with 5 brain metastases with a maximum size of approximately 4.5 cm.
She continued chemotherapy and received concomitant WBRT with 10 fractions of 3 Gy.
After 3 cycles of eribulin mesylate, treatment was discontinued because of newly diagnosed liver metastases and progression in the lungs.
No unexpected acute toxicity was observed.
The only relevant adverse reactions were haematological events after the third cycle (haemoglobin 9.5 g/dL, leukocytes 3.1×109/L).
The patient died from respiratory failure 18.5 months from diagnosis of metastatic disease, and 2.7 months from diagnosis of brain metastases.
To the best of our knowledge, this is the first report on combined WBRT and eribulin mesylate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nieder, Carsten& Aandahl, Gro& Dalhaug, Astrid. 2012. A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-479589
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nieder, Carsten…[et al.]. A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-479589
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nieder, Carsten& Aandahl, Gro& Dalhaug, Astrid. A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-479589
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479589
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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