A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate
Joint Authors
Nieder, Carsten
Dalhaug, Astrid
Aandahl, Gro
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Patients with triple receptor-negative breast cancer often develop aggressive metastatic disease, which also might involve the brain.
In many cases, systemic and local treatment is needed.
It is important to consider the toxicity of chemo- and radiotherapy, especially when newly approved drugs become available.
Randomised studies leading to drug approval often exclude patients with newly diagnosed brain metastases.
Here we report our initial experience with eribulin mesylate and whole-brain radiotherapy (WBRT) in a heavily pretreated patient with multiple brain, lung, and bone metastases from triple receptor-negative breast cancer.
Eribulin mesylate was given after 4 previous lines for metastatic disease.
Two weeks after the initial dose, that is, during the first cycle, the patient was diagnosed with 5 brain metastases with a maximum size of approximately 4.5 cm.
She continued chemotherapy and received concomitant WBRT with 10 fractions of 3 Gy.
After 3 cycles of eribulin mesylate, treatment was discontinued because of newly diagnosed liver metastases and progression in the lungs.
No unexpected acute toxicity was observed.
The only relevant adverse reactions were haematological events after the third cycle (haemoglobin 9.5 g/dL, leukocytes 3.1×109/L).
The patient died from respiratory failure 18.5 months from diagnosis of metastatic disease, and 2.7 months from diagnosis of brain metastases.
To the best of our knowledge, this is the first report on combined WBRT and eribulin mesylate.
American Psychological Association (APA)
Nieder, Carsten& Aandahl, Gro& Dalhaug, Astrid. 2012. A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-479589
Modern Language Association (MLA)
Nieder, Carsten…[et al.]. A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-479589
American Medical Association (AMA)
Nieder, Carsten& Aandahl, Gro& Dalhaug, Astrid. A Case of Brain Metastases from Breast Cancer Treated with Whole-Brain Radiotherapy and Eribulin Mesylate. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-479589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479589