Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study
المؤلفون المشاركون
Jajodia, Ajay
Kukreti, Ritushree
Kaur, Harpreet
Dhanachandra Singh, Kh.
Karthikeyan, Muthusamy
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Renin-angiotensin system (RAS) polymorphisms have been studied as candidate risk factors for hypertension with inconsistent results, possibly due to heterogeneity among various genetic and environmental factors.
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three RAS genes: AGT M235T (rs699), ACE I/D (rs4340) and G2350A (rs4343), and AGTR1 A1166C (rs5186) in essential hypertensive patients.
A total of 211 cases and 211 controls were recruited for this study.
Genotyping was performed using PCR-RFLP method.
The genotype and allele distribution of the M235T variant differed significantly in hypertensives and normotensives (OR-CI = 2.62 (1.24–5.76), P=0.006; OR-CI = 0.699 (0.518–0.943), P=0.018), respectively.
When the samples were segregated based on sex, the 235TT genotype and T allele were predominant in the female patients (OR-CI = 5.68 (1.60-25.10), P=0.002; OR-CI = 0.522 (0.330–0.826), P=0.005) as compare to the male patients (OR-CI = 1.54 (1.24–5.76), P=0.34; OR-CI = 0.874 (0.330–0.826), P=0.506), respectively.
For ACE DD variant, we found overrepresentation of “I”-allele (homozygous II and heterozygous ID) in unaffected males which suggest its protective role in studied population (OR-CI = 0.401 (0.224–0.718); P=0.0009).
The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhanachandra Singh, Kh.& Jajodia, Ajay& Kaur, Harpreet& Kukreti, Ritushree& Karthikeyan, Muthusamy. 2014. Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-479672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhanachandra Singh, Kh.…[et al.]. Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-479672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhanachandra Singh, Kh.& Jajodia, Ajay& Kaur, Harpreet& Kukreti, Ritushree& Karthikeyan, Muthusamy. Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-479672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر