Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study
Joint Authors
Jajodia, Ajay
Kukreti, Ritushree
Kaur, Harpreet
Dhanachandra Singh, Kh.
Karthikeyan, Muthusamy
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Renin-angiotensin system (RAS) polymorphisms have been studied as candidate risk factors for hypertension with inconsistent results, possibly due to heterogeneity among various genetic and environmental factors.
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three RAS genes: AGT M235T (rs699), ACE I/D (rs4340) and G2350A (rs4343), and AGTR1 A1166C (rs5186) in essential hypertensive patients.
A total of 211 cases and 211 controls were recruited for this study.
Genotyping was performed using PCR-RFLP method.
The genotype and allele distribution of the M235T variant differed significantly in hypertensives and normotensives (OR-CI = 2.62 (1.24–5.76), P=0.006; OR-CI = 0.699 (0.518–0.943), P=0.018), respectively.
When the samples were segregated based on sex, the 235TT genotype and T allele were predominant in the female patients (OR-CI = 5.68 (1.60-25.10), P=0.002; OR-CI = 0.522 (0.330–0.826), P=0.005) as compare to the male patients (OR-CI = 1.54 (1.24–5.76), P=0.34; OR-CI = 0.874 (0.330–0.826), P=0.506), respectively.
For ACE DD variant, we found overrepresentation of “I”-allele (homozygous II and heterozygous ID) in unaffected males which suggest its protective role in studied population (OR-CI = 0.401 (0.224–0.718); P=0.0009).
The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.
American Psychological Association (APA)
Dhanachandra Singh, Kh.& Jajodia, Ajay& Kaur, Harpreet& Kukreti, Ritushree& Karthikeyan, Muthusamy. 2014. Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-479672
Modern Language Association (MLA)
Dhanachandra Singh, Kh.…[et al.]. Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-479672
American Medical Association (AMA)
Dhanachandra Singh, Kh.& Jajodia, Ajay& Kaur, Harpreet& Kukreti, Ritushree& Karthikeyan, Muthusamy. Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension : A Case-Control Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-479672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479672