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Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens
المؤلفون المشاركون
Speringer, Franz
Zutz, Christoph
Bandian, Dragana
Strauss, Joseph
Gorfer, Markus
Neumayer, Bernhard
Wagner, Martin
Rychli, Kathrin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
For decades, fungi have been the main source for the discovery of novel antimicrobial drugs.
Recent sequencing efforts revealed a still high number of so far unknown “cryptic” secondary metabolites.
The production of these metabolites is presumably epigenetically silenced under standard laboratory conditions.
In this study, we investigated the effect of six small mass chemicals, of which some are known to act as epigenetic modulators, on the production of antimicrobial compounds in 54 spore forming fungi.
The antimicrobial effect of fungal samples was tested against clinically facultative pathogens and multiresistant clinical isolates.
In total, 30 samples of treated fungi belonging to six different genera reduced significantly growth of different test organisms compared to the untreated fungal sample (growth log reduction 0.3–4.3).
For instance, the pellet of Penicillium restrictum grown in the presence of butyrate revealed significant higher antimicrobial activity against Staphylococcus (S.) aureus and multiresistant S.
aureus strains and displayed no cytotoxicity against human cells, thus making it an ideal candidate for antimicrobial compound discovery.
Our study shows that every presumable fungus, even well described fungi, has the potential to produce novel antimicrobial compounds and that our approach is capable of rapidly filling the pipeline for yet undiscovered antimicrobial substances.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zutz, Christoph& Bandian, Dragana& Neumayer, Bernhard& Speringer, Franz& Gorfer, Markus& Wagner, Martin…[et al.]. 2014. Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479882
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zutz, Christoph…[et al.]. Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-479882
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zutz, Christoph& Bandian, Dragana& Neumayer, Bernhard& Speringer, Franz& Gorfer, Markus& Wagner, Martin…[et al.]. Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479882
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479882
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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