Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens
Joint Authors
Speringer, Franz
Zutz, Christoph
Bandian, Dragana
Strauss, Joseph
Gorfer, Markus
Neumayer, Bernhard
Wagner, Martin
Rychli, Kathrin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
For decades, fungi have been the main source for the discovery of novel antimicrobial drugs.
Recent sequencing efforts revealed a still high number of so far unknown “cryptic” secondary metabolites.
The production of these metabolites is presumably epigenetically silenced under standard laboratory conditions.
In this study, we investigated the effect of six small mass chemicals, of which some are known to act as epigenetic modulators, on the production of antimicrobial compounds in 54 spore forming fungi.
The antimicrobial effect of fungal samples was tested against clinically facultative pathogens and multiresistant clinical isolates.
In total, 30 samples of treated fungi belonging to six different genera reduced significantly growth of different test organisms compared to the untreated fungal sample (growth log reduction 0.3–4.3).
For instance, the pellet of Penicillium restrictum grown in the presence of butyrate revealed significant higher antimicrobial activity against Staphylococcus (S.) aureus and multiresistant S.
aureus strains and displayed no cytotoxicity against human cells, thus making it an ideal candidate for antimicrobial compound discovery.
Our study shows that every presumable fungus, even well described fungi, has the potential to produce novel antimicrobial compounds and that our approach is capable of rapidly filling the pipeline for yet undiscovered antimicrobial substances.
American Psychological Association (APA)
Zutz, Christoph& Bandian, Dragana& Neumayer, Bernhard& Speringer, Franz& Gorfer, Markus& Wagner, Martin…[et al.]. 2014. Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479882
Modern Language Association (MLA)
Zutz, Christoph…[et al.]. Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-479882
American Medical Association (AMA)
Zutz, Christoph& Bandian, Dragana& Neumayer, Bernhard& Speringer, Franz& Gorfer, Markus& Wagner, Martin…[et al.]. Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479882