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Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
المؤلفون المشاركون
Hong, Qi-Sheng
Chen, Chun-Chieh
Lee, Jen-Yi
Lin, Yu-Shuang
Sureshbabul, Munisamy
Chen, Huei-Wen
Yu, Sung-Liang
Yang, Ya-Chien
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-21
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Colorectal cancer (CRC) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world.
Curcumin is a traditional medicine used for treatment of a wide variety of tumors.
However, antimetastasis mechanism of curcumin on CRC has not yet been completely investigated.
Here, we explored the underlying molecular mechanisms of curcumin on metastasis of CRC cells in vitro and in vivo.
Curcumin significantly inhibits cell migration, invasion, and colony formation in vitro and reduces tumor growth and liver metastasis in vivo.
We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells.
Curcumin inhibits focal adhesion kinase (FAK) phosphorylation and enhances the expressions of several extracellular matrix components which play a critical role in invasion and metastasis.
Curcumin reduces CD24 expression in a dose-dependent manner in CRC cells.
Moreover, E-cadherin expression is upregulated by curcumin and serves as an inhibitor of EMT.
These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Chun-Chieh& Sureshbabul, Munisamy& Chen, Huei-Wen& Lin, Yu-Shuang& Lee, Jen-Yi& Hong, Qi-Sheng…[et al.]. 2013. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-480022
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Chun-Chieh…[et al.]. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-480022
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Chun-Chieh& Sureshbabul, Munisamy& Chen, Huei-Wen& Lin, Yu-Shuang& Lee, Jen-Yi& Hong, Qi-Sheng…[et al.]. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-480022
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480022
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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