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Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
Joint Authors
Hong, Qi-Sheng
Chen, Chun-Chieh
Lee, Jen-Yi
Lin, Yu-Shuang
Sureshbabul, Munisamy
Chen, Huei-Wen
Yu, Sung-Liang
Yang, Ya-Chien
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Colorectal cancer (CRC) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world.
Curcumin is a traditional medicine used for treatment of a wide variety of tumors.
However, antimetastasis mechanism of curcumin on CRC has not yet been completely investigated.
Here, we explored the underlying molecular mechanisms of curcumin on metastasis of CRC cells in vitro and in vivo.
Curcumin significantly inhibits cell migration, invasion, and colony formation in vitro and reduces tumor growth and liver metastasis in vivo.
We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells.
Curcumin inhibits focal adhesion kinase (FAK) phosphorylation and enhances the expressions of several extracellular matrix components which play a critical role in invasion and metastasis.
Curcumin reduces CD24 expression in a dose-dependent manner in CRC cells.
Moreover, E-cadherin expression is upregulated by curcumin and serves as an inhibitor of EMT.
These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells.
American Psychological Association (APA)
Chen, Chun-Chieh& Sureshbabul, Munisamy& Chen, Huei-Wen& Lin, Yu-Shuang& Lee, Jen-Yi& Hong, Qi-Sheng…[et al.]. 2013. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-480022
Modern Language Association (MLA)
Chen, Chun-Chieh…[et al.]. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-480022
American Medical Association (AMA)
Chen, Chun-Chieh& Sureshbabul, Munisamy& Chen, Huei-Wen& Lin, Yu-Shuang& Lee, Jen-Yi& Hong, Qi-Sheng…[et al.]. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-480022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480022