Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS
المؤلفون المشاركون
Haeussinger, Florian B.
Laeger, Inga
Vennewald, Nadja
Notzon, Swantje
Deppermann, Saskia
Arolt, Volker
Sickinger, Stephanie
Ehlis, Ann-Christine
Diemer, Julia
Fallgatter, Andreas J.
Zwanzger, Peter
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objectives.
Neurobiologically, panic disorder (PD) is supposed to be characterised by cerebral hypofrontality.
Via functional near-infrared spectroscopy (fNIRS), we investigated whether prefrontal hypoactivity during cognitive tasks in PD-patients compared to healthy controls (HC) could be replicated.
As intermittent theta burst stimulation (iTBS) modulates cortical activity, we furthermore investigated its ability to normalise prefrontal activation.
Methods.
Forty-four PD-patients, randomised to sham or verum group, received 15 iTBS-sessions above the left dorsolateral prefrontal cortex (DLPFC) in addition to psychoeducation.
Before first and after last iTBS-treatment, cortical activity during a verbal fluency task was assessed via fNIRS and compared to the results of 23 HC.
Results.
At baseline, PD-patients showed hypofrontality including the DLPFC, which differed significantly from activation patterns of HC.
However, verum iTBS did not augment prefrontal fNIRS activation.
Solely after sham iTBS, a significant increase of measured fNIRS activation in the left inferior frontal gyrus (IFG) during the phonological task was found.
Conclusion.
Our results support findings that PD is characterised by prefrontal hypoactivation during cognitive performance.
However, verum iTBS as an “add-on” to psychoeducation did not augment prefrontal activity.
Instead we only found increased fNIRS activation in the left IFG after sham iTBS application.
Possible reasons including task-related psychophysiological arousal are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deppermann, Saskia& Vennewald, Nadja& Diemer, Julia& Sickinger, Stephanie& Haeussinger, Florian B.& Notzon, Swantje…[et al.]. 2014. Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480107
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deppermann, Saskia…[et al.]. Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-480107
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deppermann, Saskia& Vennewald, Nadja& Diemer, Julia& Sickinger, Stephanie& Haeussinger, Florian B.& Notzon, Swantje…[et al.]. Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480107
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480107
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر