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Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS
Joint Authors
Haeussinger, Florian B.
Laeger, Inga
Vennewald, Nadja
Notzon, Swantje
Deppermann, Saskia
Arolt, Volker
Sickinger, Stephanie
Ehlis, Ann-Christine
Diemer, Julia
Fallgatter, Andreas J.
Zwanzger, Peter
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
Neurobiologically, panic disorder (PD) is supposed to be characterised by cerebral hypofrontality.
Via functional near-infrared spectroscopy (fNIRS), we investigated whether prefrontal hypoactivity during cognitive tasks in PD-patients compared to healthy controls (HC) could be replicated.
As intermittent theta burst stimulation (iTBS) modulates cortical activity, we furthermore investigated its ability to normalise prefrontal activation.
Methods.
Forty-four PD-patients, randomised to sham or verum group, received 15 iTBS-sessions above the left dorsolateral prefrontal cortex (DLPFC) in addition to psychoeducation.
Before first and after last iTBS-treatment, cortical activity during a verbal fluency task was assessed via fNIRS and compared to the results of 23 HC.
Results.
At baseline, PD-patients showed hypofrontality including the DLPFC, which differed significantly from activation patterns of HC.
However, verum iTBS did not augment prefrontal fNIRS activation.
Solely after sham iTBS, a significant increase of measured fNIRS activation in the left inferior frontal gyrus (IFG) during the phonological task was found.
Conclusion.
Our results support findings that PD is characterised by prefrontal hypoactivation during cognitive performance.
However, verum iTBS as an “add-on” to psychoeducation did not augment prefrontal activity.
Instead we only found increased fNIRS activation in the left IFG after sham iTBS application.
Possible reasons including task-related psychophysiological arousal are discussed.
American Psychological Association (APA)
Deppermann, Saskia& Vennewald, Nadja& Diemer, Julia& Sickinger, Stephanie& Haeussinger, Florian B.& Notzon, Swantje…[et al.]. 2014. Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480107
Modern Language Association (MLA)
Deppermann, Saskia…[et al.]. Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-480107
American Medical Association (AMA)
Deppermann, Saskia& Vennewald, Nadja& Diemer, Julia& Sickinger, Stephanie& Haeussinger, Florian B.& Notzon, Swantje…[et al.]. Does rTMS Alter Neurocognitive Functioning in Patients with Panic DisorderAgoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480107