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Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
المؤلفون المشاركون
Butler, Ian S.
Hadjikakou, Sotiris K.
Kourkoumelis, Nikolaos
Abdellah, Mohamed A.
Karkabounas, Spyros
Hadjiliadis, Nick
Barsan, Mirela M.
Kubicki, Maciej
Bakas, Thomas
Simos, Yannis V.
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-04-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide.
The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, H1, S119n-NMR, UV/Vis spectroscopy, and Mass spectroscopy.
The X-ray crystal structures of complexes 1 and 2 have also been determined.
Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value.
Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdellah, Mohamed A.& Hadjikakou, Sotiris K.& Hadjiliadis, Nick& Kubicki, Maciej& Bakas, Thomas& Kourkoumelis, Nikolaos…[et al.]. 2009. Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-480158
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdellah, Mohamed A.…[et al.]. Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-480158
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdellah, Mohamed A.& Hadjikakou, Sotiris K.& Hadjiliadis, Nick& Kubicki, Maciej& Bakas, Thomas& Kourkoumelis, Nikolaos…[et al.]. Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-480158
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480158
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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