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Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
Joint Authors
Butler, Ian S.
Hadjikakou, Sotiris K.
Kourkoumelis, Nikolaos
Abdellah, Mohamed A.
Karkabounas, Spyros
Hadjiliadis, Nick
Barsan, Mirela M.
Kubicki, Maciej
Bakas, Thomas
Simos, Yannis V.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide.
The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, H1, S119n-NMR, UV/Vis spectroscopy, and Mass spectroscopy.
The X-ray crystal structures of complexes 1 and 2 have also been determined.
Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value.
Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.
American Psychological Association (APA)
Abdellah, Mohamed A.& Hadjikakou, Sotiris K.& Hadjiliadis, Nick& Kubicki, Maciej& Bakas, Thomas& Kourkoumelis, Nikolaos…[et al.]. 2009. Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-480158
Modern Language Association (MLA)
Abdellah, Mohamed A.…[et al.]. Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-480158
American Medical Association (AMA)
Abdellah, Mohamed A.& Hadjikakou, Sotiris K.& Hadjiliadis, Nick& Kubicki, Maciej& Bakas, Thomas& Kourkoumelis, Nikolaos…[et al.]. Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-480158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480158