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Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents
المؤلفون المشاركون
Watanabe, Makoto
Fukuda, Yuh
Ogawa, Shunichi
Nagi-Miura, Noriko
Ohno, Naohito
Itoh, Yasuhiko
Tajima, Hanako
Tsuchiya, Shinichi
Ohashi, Ryuji
Fukazawa, Ryuji
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Coronary arteritis, a complication of Kawasaki disease (KD), can be refractory to immunoglobulin (IVIG) treatment.
To determine the most effective alternative therapy, we compared the efficacy of different agents in a mouse model of KD.
Vasculitis was induced by injection of Candida albicans water-soluble fractions (CAWS) into a DBA/2 mouse, followed by administration of IVIG, etanercept, methylprednisolone (MP), and cyclosporine-A (CsA).
At 2 and 4 weeks, the mice were sacrificed, and plasma cytokines and chemokines were measured.
CAWS injection induced active inflammation in the aortic root and coronary arteries.
At 2 weeks, the vasculitis was reduced only by etanercept, and this effect persisted for the subsequent 2 weeks.
At 4 weeks, IVIG and CsA also attenuated the inflammation, but the effect of etanercept was more significant.
MP exerted no apparent effect at 2 or 4 weeks.
The suppressive effect exerted by etanercept on cytokines, such as interleukin- (IL-)6, IL-12, IL-13, and tumor necrosis factor-α (TNF-α), was more evident than that of others.
The extent of arteritis correlated with the plasma TNF-α levels, suggesting a pivotal role of TNF-α in KD.
In conclusion, etanercept was most effective in suppressing CAWS-induced vasculitis and can be a new therapeutic intervention for KD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohashi, Ryuji& Fukazawa, Ryuji& Watanabe, Makoto& Tajima, Hanako& Nagi-Miura, Noriko& Ohno, Naohito…[et al.]. 2013. Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-480174
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohashi, Ryuji…[et al.]. Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents. International Journal of Vascular Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-480174
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohashi, Ryuji& Fukazawa, Ryuji& Watanabe, Makoto& Tajima, Hanako& Nagi-Miura, Noriko& Ohno, Naohito…[et al.]. Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-480174
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480174
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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