Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents
Joint Authors
Watanabe, Makoto
Fukuda, Yuh
Ogawa, Shunichi
Nagi-Miura, Noriko
Ohno, Naohito
Itoh, Yasuhiko
Tajima, Hanako
Tsuchiya, Shinichi
Ohashi, Ryuji
Fukazawa, Ryuji
Source
International Journal of Vascular Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Coronary arteritis, a complication of Kawasaki disease (KD), can be refractory to immunoglobulin (IVIG) treatment.
To determine the most effective alternative therapy, we compared the efficacy of different agents in a mouse model of KD.
Vasculitis was induced by injection of Candida albicans water-soluble fractions (CAWS) into a DBA/2 mouse, followed by administration of IVIG, etanercept, methylprednisolone (MP), and cyclosporine-A (CsA).
At 2 and 4 weeks, the mice were sacrificed, and plasma cytokines and chemokines were measured.
CAWS injection induced active inflammation in the aortic root and coronary arteries.
At 2 weeks, the vasculitis was reduced only by etanercept, and this effect persisted for the subsequent 2 weeks.
At 4 weeks, IVIG and CsA also attenuated the inflammation, but the effect of etanercept was more significant.
MP exerted no apparent effect at 2 or 4 weeks.
The suppressive effect exerted by etanercept on cytokines, such as interleukin- (IL-)6, IL-12, IL-13, and tumor necrosis factor-α (TNF-α), was more evident than that of others.
The extent of arteritis correlated with the plasma TNF-α levels, suggesting a pivotal role of TNF-α in KD.
In conclusion, etanercept was most effective in suppressing CAWS-induced vasculitis and can be a new therapeutic intervention for KD.
American Psychological Association (APA)
Ohashi, Ryuji& Fukazawa, Ryuji& Watanabe, Makoto& Tajima, Hanako& Nagi-Miura, Noriko& Ohno, Naohito…[et al.]. 2013. Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-480174
Modern Language Association (MLA)
Ohashi, Ryuji…[et al.]. Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents. International Journal of Vascular Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-480174
American Medical Association (AMA)
Ohashi, Ryuji& Fukazawa, Ryuji& Watanabe, Makoto& Tajima, Hanako& Nagi-Miura, Noriko& Ohno, Naohito…[et al.]. Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease : A Comparative Study Involving Different Biological Agents. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-480174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480174