Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation
المؤلفون المشاركون
Ma, Yongsheng
Wang, Wenbo
Zhang, Lin
Qu, Hongyan
Rong, Shengzhong
Chang, Dong
Zhang, Yannan
Pan, Hongzhi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Objects.
The aim of this study is to evaluate protein oxidation, DNA damage, and lipid peroxidation in patients with gastric cancer and to investigate the relationship between oxidative stress and gastric cancer.
Methods.
We investigated changes in serum protein carbonyl (PC), advanced oxidation protein products (AOPP), and 3-nitrotyrosine (3-NT) levels, as indicators of protein oxidation, serum 8-hydroxydeoxyguanosine (8-OHdG), as a biomarker of DNA damage, and malondialdehyde (MDA), conjugated diene (CD), 4-hydroxynonenal (4-HNE), and 8-ISO-prostaglandin F2α (8-PGF) in serum, as lipid peroxidation markers in gastric cancer (GC) patients and healthy control.
Results.
Compared with control, a statistically significant higher values of 8-OHdG, PC, AOPP, and 3-NT were observed in the GC patients (P<0.05).
The products of lipid peroxidation, MDA, CD, 4-HNE, and 8-PGF, were significantly lower in the GC patients compared to those of control (P<0.05).
In addition, the products of oxidative stress were similar between the Helicobacter pylori positive and the negative subgroups of GC patients.
Conclusions.
GC patients were characterized by increased protein oxidation and DNA damage, and decreased lipid peroxidation.
Assessment of oxidative stress and augmentation of the antioxidant defense system may be important for the treatment and prevention of gastric carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Yongsheng& Zhang, Lin& Rong, Shengzhong& Qu, Hongyan& Zhang, Yannan& Chang, Dong…[et al.]. 2013. Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480232
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Yongsheng…[et al.]. Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-480232
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Yongsheng& Zhang, Lin& Rong, Shengzhong& Qu, Hongyan& Zhang, Yannan& Chang, Dong…[et al.]. Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480232
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480232
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر