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Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation
Joint Authors
Ma, Yongsheng
Wang, Wenbo
Zhang, Lin
Qu, Hongyan
Rong, Shengzhong
Chang, Dong
Zhang, Yannan
Pan, Hongzhi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Objects.
The aim of this study is to evaluate protein oxidation, DNA damage, and lipid peroxidation in patients with gastric cancer and to investigate the relationship between oxidative stress and gastric cancer.
Methods.
We investigated changes in serum protein carbonyl (PC), advanced oxidation protein products (AOPP), and 3-nitrotyrosine (3-NT) levels, as indicators of protein oxidation, serum 8-hydroxydeoxyguanosine (8-OHdG), as a biomarker of DNA damage, and malondialdehyde (MDA), conjugated diene (CD), 4-hydroxynonenal (4-HNE), and 8-ISO-prostaglandin F2α (8-PGF) in serum, as lipid peroxidation markers in gastric cancer (GC) patients and healthy control.
Results.
Compared with control, a statistically significant higher values of 8-OHdG, PC, AOPP, and 3-NT were observed in the GC patients (P<0.05).
The products of lipid peroxidation, MDA, CD, 4-HNE, and 8-PGF, were significantly lower in the GC patients compared to those of control (P<0.05).
In addition, the products of oxidative stress were similar between the Helicobacter pylori positive and the negative subgroups of GC patients.
Conclusions.
GC patients were characterized by increased protein oxidation and DNA damage, and decreased lipid peroxidation.
Assessment of oxidative stress and augmentation of the antioxidant defense system may be important for the treatment and prevention of gastric carcinogenesis.
American Psychological Association (APA)
Ma, Yongsheng& Zhang, Lin& Rong, Shengzhong& Qu, Hongyan& Zhang, Yannan& Chang, Dong…[et al.]. 2013. Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480232
Modern Language Association (MLA)
Ma, Yongsheng…[et al.]. Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-480232
American Medical Association (AMA)
Ma, Yongsheng& Zhang, Lin& Rong, Shengzhong& Qu, Hongyan& Zhang, Yannan& Chang, Dong…[et al.]. Relation between Gastric Cancer and Protein Oxidation, DNA Damage, and Lipid Peroxidation. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480232