Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry
المؤلفون المشاركون
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) as a microextraction solvent was proposed to preconcentrate terazosin.
The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution.
Due to the presence of the common ion, the solubility of IL significantly decreased.
As a result, the phase separation successfully occurred even at high ionic strength, and the volume of the settled IL-phase was not influenced by variations in the ionic strength (up to 30% w/v).
After preconcentration step, the enriched phase was introduced to the spectrofluorimeter for the determination of terazosin.
The obtained results revealed that this system did not suffer from the limitations of that in conventional ionic-liquid microextraction.
Under optimum experimental conditions, the proposed method provided a limit of detection (LOD) of 0.027 μg L−1 and a relative standard deviation (R.S.D.) of 2.4%.
The present method was successfully applied to terazosin determination in actual pharmaceutical formulations and biological samples.
Considering the large variety of ionic liquids, the proposed microextraction method earns many merits, and will present a wide application in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeeb, Mohsen& Sadeghi, Mahdi. 2012. Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry. International Journal of Analytical Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480359
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeeb, Mohsen& Sadeghi, Mahdi. Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry. International Journal of Analytical Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-480359
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeeb, Mohsen& Sadeghi, Mahdi. Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry. International Journal of Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480359
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480359
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر