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Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry
Joint Authors
Source
International Journal of Analytical Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) as a microextraction solvent was proposed to preconcentrate terazosin.
The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution.
Due to the presence of the common ion, the solubility of IL significantly decreased.
As a result, the phase separation successfully occurred even at high ionic strength, and the volume of the settled IL-phase was not influenced by variations in the ionic strength (up to 30% w/v).
After preconcentration step, the enriched phase was introduced to the spectrofluorimeter for the determination of terazosin.
The obtained results revealed that this system did not suffer from the limitations of that in conventional ionic-liquid microextraction.
Under optimum experimental conditions, the proposed method provided a limit of detection (LOD) of 0.027 μg L−1 and a relative standard deviation (R.S.D.) of 2.4%.
The present method was successfully applied to terazosin determination in actual pharmaceutical formulations and biological samples.
Considering the large variety of ionic liquids, the proposed microextraction method earns many merits, and will present a wide application in the future.
American Psychological Association (APA)
Zeeb, Mohsen& Sadeghi, Mahdi. 2012. Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry. International Journal of Analytical Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480359
Modern Language Association (MLA)
Zeeb, Mohsen& Sadeghi, Mahdi. Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry. International Journal of Analytical Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-480359
American Medical Association (AMA)
Zeeb, Mohsen& Sadeghi, Mahdi. Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry. International Journal of Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480359