Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications
المؤلفون المشاركون
Han, Han
Liang, Gangning
Wolff, Erika M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Urothelial carcinoma (UC), the most common type of bladder cancer, is one of the most expensive malignancies to treat due to its high rate of recurrence.
The characterization of the genetic alterations associated with UC has revealed the presence of two mutually exclusive molecular pathways along which distinct genetic abnormalities contribute to the formation of invasive and noninvasive tumors.
Here, we focus on the epigenetic alterations found in UC, including the presence of an epigenetic field defect throughout bladders with tumors.
A distinct hypomethylation pattern was found in noninvasive tumors, whereas widespread hypermethylation was found in invasive tumors, indicating the two pathways given rise to two tumor types also differ epigenetically.
Since certain epigenetic alterations precede histopathological changes, they can serve as excellent markers for the development of diagnostic, prognostic, and surveillance tools.
In addition, their dynamic nature and reversibility with pharmacological interventions open new and exciting avenues for therapies.
The epigenetic abnormalities associated with UC would make it an excellent target for epigenetic therapy, which is currently approved for the treatment of a few hematological malignancies.
Future research is needed to address efficacy and potential toxicity issues before it can be implemented as a therapeutic strategy for solid tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Han& Wolff, Erika M.& Liang, Gangning. 2012. Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications. Advances in Urology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-480413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Han…[et al.]. Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications. Advances in Urology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-480413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Han& Wolff, Erika M.& Liang, Gangning. Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-480413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر