Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications
Joint Authors
Han, Han
Liang, Gangning
Wolff, Erika M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Urothelial carcinoma (UC), the most common type of bladder cancer, is one of the most expensive malignancies to treat due to its high rate of recurrence.
The characterization of the genetic alterations associated with UC has revealed the presence of two mutually exclusive molecular pathways along which distinct genetic abnormalities contribute to the formation of invasive and noninvasive tumors.
Here, we focus on the epigenetic alterations found in UC, including the presence of an epigenetic field defect throughout bladders with tumors.
A distinct hypomethylation pattern was found in noninvasive tumors, whereas widespread hypermethylation was found in invasive tumors, indicating the two pathways given rise to two tumor types also differ epigenetically.
Since certain epigenetic alterations precede histopathological changes, they can serve as excellent markers for the development of diagnostic, prognostic, and surveillance tools.
In addition, their dynamic nature and reversibility with pharmacological interventions open new and exciting avenues for therapies.
The epigenetic abnormalities associated with UC would make it an excellent target for epigenetic therapy, which is currently approved for the treatment of a few hematological malignancies.
Future research is needed to address efficacy and potential toxicity issues before it can be implemented as a therapeutic strategy for solid tumors.
American Psychological Association (APA)
Han, Han& Wolff, Erika M.& Liang, Gangning. 2012. Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications. Advances in Urology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-480413
Modern Language Association (MLA)
Han, Han…[et al.]. Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications. Advances in Urology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-480413
American Medical Association (AMA)
Han, Han& Wolff, Erika M.& Liang, Gangning. Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-480413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480413