Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia
المؤلفون المشاركون
Ruan, Changgeng
Wang, Zhaoyue
Li, Jiaming
Yu, Ziqiang
Cao, Lijuan
Bai, Xia
Dai, Lan
Su, Jian
Zhu, Mingqing
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We conducted this randomized trial to investigate the efficacy and safety of rapamycin treatment in adults with chronic immune thrombocytopenia (ITP).
Eighty-eight patients were separated into the control (cyclosporine A plus prednisone) and experimental (rapamycin plus prednisone) groups.
The CD4+CD25+CD127low regulatory T (Treg) cells level, Foxp3 mRNA expression, and the relevant cytokines levels were measured before and after treatment.
The overall response (OR) was similar in both groups (experimental group versus control group: 58% versus 62%, P=0.70).
However, sustained response (SR) was more pronounced in the experimental group than in the control group (68% versus 39%, P<0.05).
Both groups showed similar incidence of adverse events (7% versus 11%, P=0.51).
As expected, the low pretreatment baseline level of Treg cells was seen in all patients (P<0.001); however, the experimental group experienced a significant rise in Treg cell level, and there was a strong correlation between the levels of Treg cells and TGF-beta after the treatment.
In addition, the upregulation maintained a stable level during the follow-up phase.
Thus, rapamycin plus low dose prednisone could provide a new promising option for therapy of ITP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jiaming& Wang, Zhaoyue& Dai, Lan& Cao, Lijuan& Su, Jian& Zhu, Mingqing…[et al.]. 2013. Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jiaming…[et al.]. Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jiaming& Wang, Zhaoyue& Dai, Lan& Cao, Lijuan& Su, Jian& Zhu, Mingqing…[et al.]. Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر