Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia
Joint Authors
Ruan, Changgeng
Wang, Zhaoyue
Li, Jiaming
Yu, Ziqiang
Cao, Lijuan
Bai, Xia
Dai, Lan
Su, Jian
Zhu, Mingqing
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We conducted this randomized trial to investigate the efficacy and safety of rapamycin treatment in adults with chronic immune thrombocytopenia (ITP).
Eighty-eight patients were separated into the control (cyclosporine A plus prednisone) and experimental (rapamycin plus prednisone) groups.
The CD4+CD25+CD127low regulatory T (Treg) cells level, Foxp3 mRNA expression, and the relevant cytokines levels were measured before and after treatment.
The overall response (OR) was similar in both groups (experimental group versus control group: 58% versus 62%, P=0.70).
However, sustained response (SR) was more pronounced in the experimental group than in the control group (68% versus 39%, P<0.05).
Both groups showed similar incidence of adverse events (7% versus 11%, P=0.51).
As expected, the low pretreatment baseline level of Treg cells was seen in all patients (P<0.001); however, the experimental group experienced a significant rise in Treg cell level, and there was a strong correlation between the levels of Treg cells and TGF-beta after the treatment.
In addition, the upregulation maintained a stable level during the follow-up phase.
Thus, rapamycin plus low dose prednisone could provide a new promising option for therapy of ITP.
American Psychological Association (APA)
Li, Jiaming& Wang, Zhaoyue& Dai, Lan& Cao, Lijuan& Su, Jian& Zhu, Mingqing…[et al.]. 2013. Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480515
Modern Language Association (MLA)
Li, Jiaming…[et al.]. Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480515
American Medical Association (AMA)
Li, Jiaming& Wang, Zhaoyue& Dai, Lan& Cao, Lijuan& Su, Jian& Zhu, Mingqing…[et al.]. Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480515