LDL-CHDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone

الملخص EN

High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are strong predictors of atherosclerosis.

Statin-induced changes in the ratio of LDL-C to HDL-C (LDL-C/HDL-C) predicted atherosclerosis progression better than LDL-C or HDL-C alone.

However, the best predictor of subclinical atherosclerosis remains unknown.

Our objective was to investigate this issue by measuring changes in carotid intima-media thickness (IMT).

A total of 1,920 subjects received health examinations in 1999, and were followed up in 2007.

Changes in IMT (follow-up IMT/baseline IMT×100) were measured by ultrasonography.

Our results showed that changes in IMT after eight years were significantly related to HDL-C (inversely, P<0.05) and to LDL-C/HDL-C ratio (P<0.05).

When the LDL-C/HDL-C ratios were divided into quartiles, analysis of covariance showed that increases in the ratio were related to IMT progression (P<0.05).

This prospective study demonstrated the LDL-C/HDL-C ratio is a better predictor of IMT progression than HDL-C or LDL-C alone.