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The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls
المؤلفون المشاركون
Vassos, Evangelos
Collier, David
McDonald, Colm
Bramon, Elvira
Picchioni, Marco
Murray, Robin
Toulopoulou, Timothea
Walshe, Muriel
Shaikh, Madiha
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأمراض
الملخص EN
We investigated the influences of putative candidate genes for psychosis on premorbid social adjustment and on premorbid schizoid-schizotypal traits.
A family-based sample was used including 177 patients with schizophrenia or bipolar I disorder with a history of psychotic symptoms, 86 of their unaffected relatives, and 116 unrelated healthy controls.
Association analyses on the combined sample were conducted using the Statistical Analysis for Genetic Epidemiology software (SAGE) and adjusting for age, sex, clinical group, and the family-based nature of the data.
The COMT Val158Met and BDNF Val66Met polymorphisms showed no evidence of association with either phenotype.
The SNP rs221533 of the NRG1 gene was significantly associated with premorbid adjustment in adolescence with TT homozygous subjects having a poorer performance than C allele carriers.
In the context of neurodevelopmental disorders such as schizophrenia and other psychoses, this finding is plausible; however, it is preliminary and requires replication in an independent sample.
In a broader sense, the use of intermediate quantitative phenotypes such as the ones presented in this study may be of help to understand the mechanism of action of genetic risk factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Walshe, Muriel& Vassos, Evangelos& Picchioni, Marco& Shaikh, Madiha& Toulopoulou, Timothea& Collier, David…[et al.]. 2012. The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-480779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Walshe, Muriel…[et al.]. The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-480779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Walshe, Muriel& Vassos, Evangelos& Picchioni, Marco& Shaikh, Madiha& Toulopoulou, Timothea& Collier, David…[et al.]. The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-480779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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