The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls
Joint Authors
Vassos, Evangelos
Collier, David
McDonald, Colm
Bramon, Elvira
Picchioni, Marco
Murray, Robin
Toulopoulou, Timothea
Walshe, Muriel
Shaikh, Madiha
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
We investigated the influences of putative candidate genes for psychosis on premorbid social adjustment and on premorbid schizoid-schizotypal traits.
A family-based sample was used including 177 patients with schizophrenia or bipolar I disorder with a history of psychotic symptoms, 86 of their unaffected relatives, and 116 unrelated healthy controls.
Association analyses on the combined sample were conducted using the Statistical Analysis for Genetic Epidemiology software (SAGE) and adjusting for age, sex, clinical group, and the family-based nature of the data.
The COMT Val158Met and BDNF Val66Met polymorphisms showed no evidence of association with either phenotype.
The SNP rs221533 of the NRG1 gene was significantly associated with premorbid adjustment in adolescence with TT homozygous subjects having a poorer performance than C allele carriers.
In the context of neurodevelopmental disorders such as schizophrenia and other psychoses, this finding is plausible; however, it is preliminary and requires replication in an independent sample.
In a broader sense, the use of intermediate quantitative phenotypes such as the ones presented in this study may be of help to understand the mechanism of action of genetic risk factors.
American Psychological Association (APA)
Walshe, Muriel& Vassos, Evangelos& Picchioni, Marco& Shaikh, Madiha& Toulopoulou, Timothea& Collier, David…[et al.]. 2012. The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-480779
Modern Language Association (MLA)
Walshe, Muriel…[et al.]. The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-480779
American Medical Association (AMA)
Walshe, Muriel& Vassos, Evangelos& Picchioni, Marco& Shaikh, Madiha& Toulopoulou, Timothea& Collier, David…[et al.]. The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-480779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480779