Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients
المؤلفون المشاركون
Schiffer, Mario
Haller, Hermann G.
Kaufeld, Jessica K.
Gwinner, Wilfried
Scheffner, Irina
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is known to predict the prolonged delayed graft function after kidney transplantation.
We examined the relation of uNGAL with histological findings of acute tubular injury (ATI).
Analyses were made in biopsies taken at 6 weeks, 3 months, and 6 months after kidney transplantation.
uNGAL was measured in the spot urines, normalized to urinary creatinine excretion, and correlated to biopsy findings and clinical, laboratory, and demographic variables.
Controls included healthy individuals, individuals after kidney donation and ICU patients with acute kidney failure.
Renal transplant recipients without ATI did not display elevated uNGAL levels compared to the healthy controls.
Transplant patients with ATI had a higher uNGAL excretion at 6 weeks than patients without ATI (27,435 versus 13,605 ng/g; P=0.031).
This increase in uNGAL was minor compared to ICU patients with acute renal failure (2.05×106 ng/g).
Patients with repeated findings of ATI or severe ATI did not have higher urinary NGAL levels compared to those with only one ATI finding or moderate ATI.
Female recipient gender and urinary tract infection were identified as potential confounders.
uNGAL has a relation with histological signs of acute tubular injury.
The usability of this biomarker in renal allograft recipients is limited because of the low sensitivity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaufeld, Jessica K.& Gwinner, Wilfried& Scheffner, Irina& Haller, Hermann G.& Schiffer, Mario. 2012. Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481046
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaufeld, Jessica K.…[et al.]. Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients. Journal of Transplantation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-481046
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaufeld, Jessica K.& Gwinner, Wilfried& Scheffner, Irina& Haller, Hermann G.& Schiffer, Mario. Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481046
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481046
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر