Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients
Joint Authors
Schiffer, Mario
Haller, Hermann G.
Kaufeld, Jessica K.
Gwinner, Wilfried
Scheffner, Irina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is known to predict the prolonged delayed graft function after kidney transplantation.
We examined the relation of uNGAL with histological findings of acute tubular injury (ATI).
Analyses were made in biopsies taken at 6 weeks, 3 months, and 6 months after kidney transplantation.
uNGAL was measured in the spot urines, normalized to urinary creatinine excretion, and correlated to biopsy findings and clinical, laboratory, and demographic variables.
Controls included healthy individuals, individuals after kidney donation and ICU patients with acute kidney failure.
Renal transplant recipients without ATI did not display elevated uNGAL levels compared to the healthy controls.
Transplant patients with ATI had a higher uNGAL excretion at 6 weeks than patients without ATI (27,435 versus 13,605 ng/g; P=0.031).
This increase in uNGAL was minor compared to ICU patients with acute renal failure (2.05×106 ng/g).
Patients with repeated findings of ATI or severe ATI did not have higher urinary NGAL levels compared to those with only one ATI finding or moderate ATI.
Female recipient gender and urinary tract infection were identified as potential confounders.
uNGAL has a relation with histological signs of acute tubular injury.
The usability of this biomarker in renal allograft recipients is limited because of the low sensitivity.
American Psychological Association (APA)
Kaufeld, Jessica K.& Gwinner, Wilfried& Scheffner, Irina& Haller, Hermann G.& Schiffer, Mario. 2012. Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481046
Modern Language Association (MLA)
Kaufeld, Jessica K.…[et al.]. Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients. Journal of Transplantation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-481046
American Medical Association (AMA)
Kaufeld, Jessica K.& Gwinner, Wilfried& Scheffner, Irina& Haller, Hermann G.& Schiffer, Mario. Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients : NGAL and ATI in Renal Transplant Patients. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-481046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481046