Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats
المؤلفون المشاركون
Mothana, R. A. A.
Parvez, Mohammad Khalid
al-Musayeib, Nawal
al-Said, Mansour
al-Yahya, Mohammed
al-Dosari, Mohammed
al-Sohaibani, Mohammed
Rafatullah, Syed
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The present study was undertaken to investigate the possible protective effect of Saudi Sidr honey (SSH) on carbon tetrachloride (CCl4) induced oxidative stress and liver and kidney damage in rat.
Moreover, the antioxidant activity and the phenolic and flavonoidal contents were determined.
The hepatorenal protective activity of the SSH was determined by assessing biochemical, hematological, and histological parameters.
Serum transaminases, ALP, GGT, creatinine, bilirubin urea, uric acid, and MDA level in liver and kidney tissues were significantly elevated, and the antioxidant status of nonprotein sulfhydryls, albumin, and total protein levels in liver and kidney were declined significantly in CCl4 alone treated animals.
Pretreatment with SSH and silymarin prior to the administration of CCl4 significantly prevented the increase of the serum levels of enzyme markers and reduced oxidative stress.
SSH also exhibited a significant lipid-lowering effect and caused an HDL-C enhanced level in serum.
The histopathological evaluation of the liver and kidney also revealed that honey protected incidence of both liver and kidney lesions.
Moreover, SSH showed a strong antioxidant activity in DPPH and β-carotene-linoleic acid assays.
SSH was found to contain phenolic compounds.
Additionally, the SSH supplementation restored the hepatocytes viability against 2′,7′-dichlorofluorescein (DCF) toxicity in ex vivo test.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Yahya, Mohammed& Mothana, R. A. A.& al-Said, Mansour& al-Dosari, Mohammed& al-Musayeib, Nawal& al-Sohaibani, Mohammed…[et al.]. 2013. Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-481451
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Yahya, Mohammed…[et al.]. Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-481451
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Yahya, Mohammed& Mothana, R. A. A.& al-Said, Mansour& al-Dosari, Mohammed& al-Musayeib, Nawal& al-Sohaibani, Mohammed…[et al.]. Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-481451
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481451
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر