Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

Joint Authors

Mothana, R. A. A.
Parvez, Mohammad Khalid
al-Musayeib, Nawal
al-Said, Mansour
al-Yahya, Mohammed
al-Dosari, Mohammed
al-Sohaibani, Mohammed
Rafatullah, Syed

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-02-24

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

The present study was undertaken to investigate the possible protective effect of Saudi Sidr honey (SSH) on carbon tetrachloride (CCl4) induced oxidative stress and liver and kidney damage in rat.

Moreover, the antioxidant activity and the phenolic and flavonoidal contents were determined.

The hepatorenal protective activity of the SSH was determined by assessing biochemical, hematological, and histological parameters.

Serum transaminases, ALP, GGT, creatinine, bilirubin urea, uric acid, and MDA level in liver and kidney tissues were significantly elevated, and the antioxidant status of nonprotein sulfhydryls, albumin, and total protein levels in liver and kidney were declined significantly in CCl4 alone treated animals.

Pretreatment with SSH and silymarin prior to the administration of CCl4 significantly prevented the increase of the serum levels of enzyme markers and reduced oxidative stress.

SSH also exhibited a significant lipid-lowering effect and caused an HDL-C enhanced level in serum.

The histopathological evaluation of the liver and kidney also revealed that honey protected incidence of both liver and kidney lesions.

Moreover, SSH showed a strong antioxidant activity in DPPH and β-carotene-linoleic acid assays.

SSH was found to contain phenolic compounds.

Additionally, the SSH supplementation restored the hepatocytes viability against 2′,7′-dichlorofluorescein (DCF) toxicity in ex vivo test.

American Psychological Association (APA)

al-Yahya, Mohammed& Mothana, R. A. A.& al-Said, Mansour& al-Dosari, Mohammed& al-Musayeib, Nawal& al-Sohaibani, Mohammed…[et al.]. 2013. Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-481451

Modern Language Association (MLA)

al-Yahya, Mohammed…[et al.]. Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-481451

American Medical Association (AMA)

al-Yahya, Mohammed& Mothana, R. A. A.& al-Said, Mansour& al-Dosari, Mohammed& al-Musayeib, Nawal& al-Sohaibani, Mohammed…[et al.]. Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-481451

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-481451