A Limited Sampling, Simple, and Useful Method for Determination of Glomerular Filtration Rate in Cats by Using a New Accurate HPLC Method to Measure Iohexol Plasmatic Concentrations
المؤلفون المشاركون
Pierre, Melanie
Ilaria, Lippi
Grazia, Guidi
Valentina, Meucci
Gloria, Breghi
المصدر
Journal of Veterinary Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Glomerular filtration rate (GFR) is still a highly underutilized tool in cats because available methods are not easy to be performed in clinical practice.
Iohexol (IOX) has been shown to be a useful and reliable marker of GFR both in animals and in humans.
The aim of the present study was to develop a rapid and reliable method for measuring IOX in feline plasma and to evaluate the accuracy of limited sampling models to establish a low-cost and clinically suitable GFR test.
IOX concentrations were determined by using a new HPLC-UV method.
GFR was assessed as plasma clearance of IOX, which was calculated by dividing dose administered by area under the curve of plasmatic concentration versus time (AUC), and indexed to body weight (BW).
Correlation and agreement analysis between the GFR values obtained by a seven-point clearance method and the GFR values determined by the application of simplified sample combinations indicated that the 3-blood sample clearance model (5, 30, and 60 min) was the best simplified method because it provided an accurate GFR value in only one hour.
The reported method is a simple and accurate way of GFR determination, which may be easily used in a clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Valentina, Meucci& Grazia, Guidi& Pierre, Melanie& Gloria, Breghi& Ilaria, Lippi. 2013. A Limited Sampling, Simple, and Useful Method for Determination of Glomerular Filtration Rate in Cats by Using a New Accurate HPLC Method to Measure Iohexol Plasmatic Concentrations. Journal of Veterinary Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-481465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Valentina, Meucci…[et al.]. A Limited Sampling, Simple, and Useful Method for Determination of Glomerular Filtration Rate in Cats by Using a New Accurate HPLC Method to Measure Iohexol Plasmatic Concentrations. Journal of Veterinary Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-481465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Valentina, Meucci& Grazia, Guidi& Pierre, Melanie& Gloria, Breghi& Ilaria, Lippi. A Limited Sampling, Simple, and Useful Method for Determination of Glomerular Filtration Rate in Cats by Using a New Accurate HPLC Method to Measure Iohexol Plasmatic Concentrations. Journal of Veterinary Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-481465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر