Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production
المؤلفون المشاركون
Lee, Young-Chul
Jeon, Bo Ra
Im, Eun Ju
Park, Ji Young
Jia, Qi
Lee, Joo Young
Son, Young Min
Park, Hwa-Jin
Lee, Dong-Ha
Rhee, Man Hee
Ji, Hyun Dong
Hyun, Eujin
Hong, Mei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
A number of reagents that prevent thrombosis have been developed but were found to have serious side effects.
Therefore, we sought to identify complementary and alternative medicinal materials that are safe and have long-term efficacy.
In the present studies, we have assessed the ability of chlorine e6 (CE6) to inhibit ADP-induced aggregation of rat platelets and elucidated the underlying mechanism.
CE6 inhibited platelet aggregation induced by 10 µM ADP in a concentration-dependent manner and decreased intracellular calcium mobilization and granule secretion (i.e., ATP and serotonin release).
Western blotting revealed that CE6 strongly inhibited the phosphorylations of PI3K, Akt, c-Jun N-terminal kinase (JNK), and different mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (ERK1/2) as well as p38-MAPK.
Our study also demonstrated that CE6 significantly elevated intracellular cAMP levels and decreased thromboxane A2 formation in a concentration-dependent manner.
Furthermore, we determined that CE6 initiated the activation of PKA, an effector of cAMP.
Taken together, our findings indicate that CE6 may inhibit ADP-induced platelet activation by elevating cAMP levels and suppressing PI3K/Akt activity.
Finally, these results suggest that CE6 could be developed as therapeutic agent that helps prevent thrombosis and ischemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Ji Young& Ji, Hyun Dong& Jeon, Bo Ra& Im, Eun Ju& Son, Young Min& Lee, Joo Young…[et al.]. 2013. Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-481473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Ji Young…[et al.]. Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-481473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Ji Young& Ji, Hyun Dong& Jeon, Bo Ra& Im, Eun Ju& Son, Young Min& Lee, Joo Young…[et al.]. Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-481473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر