Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats
المؤلفون المشاركون
Tayem, Yasin I.
Matar, Kamal M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
We aimed to investigate the effect of induced hepatic and renal failure on the pharmacokinetics of topiramate (TPM) in rats.
Twenty-four Sprague-Dawley rats were used in this study.
Renal or hepatic failure was induced by a single i.p.
dose of 7.5 mg/kg cisplatin (n=8) or 0.5 mL/kg carbon tetrachloride (CCl4) (n=8), respectively.
Three days after cisplatin dose or 24 h after CCl4 dose, the rats were administered a single oral dose of 20 mg/kg TPM.
The plasma samples were quantified by LC-MS/MS method.
Compared to control, plasma concentration-time profile in CCl4-treated and, to a lesser extent, in cisplatin-treated rats decreased more slowly particularly in the elimination phase.
TPM oral clearance (CL/F) in CCl4-treated group was significantly lower than that in control (P<0.001), whereas AUC0−∞, T1/2, and Vd/F were significantly higher in CCl4-treated rats compared to the control (P<0.01).
The CL/F was not significantly different between cisplatin-treated rats and control (P>0.05).
However, in cisplatin-treated rats, the T1/2 and Vd/F were significantly higher than that in the control group (P<0.01).
Both conditions failed to cause a significant effect on Cmax or Tmax.
The present findings suggest that induced hepatic or renal failure could modify the pharmacokinetic profile of TPM in the rat.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matar, Kamal M.& Tayem, Yasin I.. 2014. Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-481619
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matar, Kamal M.& Tayem, Yasin I.. Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-481619
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matar, Kamal M.& Tayem, Yasin I.. Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-481619
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481619
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر