![](/images/graphics-bg.png)
Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats
Joint Authors
Tayem, Yasin I.
Matar, Kamal M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We aimed to investigate the effect of induced hepatic and renal failure on the pharmacokinetics of topiramate (TPM) in rats.
Twenty-four Sprague-Dawley rats were used in this study.
Renal or hepatic failure was induced by a single i.p.
dose of 7.5 mg/kg cisplatin (n=8) or 0.5 mL/kg carbon tetrachloride (CCl4) (n=8), respectively.
Three days after cisplatin dose or 24 h after CCl4 dose, the rats were administered a single oral dose of 20 mg/kg TPM.
The plasma samples were quantified by LC-MS/MS method.
Compared to control, plasma concentration-time profile in CCl4-treated and, to a lesser extent, in cisplatin-treated rats decreased more slowly particularly in the elimination phase.
TPM oral clearance (CL/F) in CCl4-treated group was significantly lower than that in control (P<0.001), whereas AUC0−∞, T1/2, and Vd/F were significantly higher in CCl4-treated rats compared to the control (P<0.01).
The CL/F was not significantly different between cisplatin-treated rats and control (P>0.05).
However, in cisplatin-treated rats, the T1/2 and Vd/F were significantly higher than that in the control group (P<0.01).
Both conditions failed to cause a significant effect on Cmax or Tmax.
The present findings suggest that induced hepatic or renal failure could modify the pharmacokinetic profile of TPM in the rat.
American Psychological Association (APA)
Matar, Kamal M.& Tayem, Yasin I.. 2014. Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-481619
Modern Language Association (MLA)
Matar, Kamal M.& Tayem, Yasin I.. Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-481619
American Medical Association (AMA)
Matar, Kamal M.& Tayem, Yasin I.. Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-481619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481619